Invasion Mechanisms in Angiogenesis and Cancer team (IMAC)
Mechanisms of Angiogenesis in Biological Barriers team (MAB2)
Angiogenesis and lymphangiogenesis, which correspond to the formation of new blood and lymphatic vessels from existing vessels, are two major processes involved in physiological development, but also in tumoral development and metastatic dissemination. To address this question, the team is working on a new signalling pathway specific to the vascular system mediated by the transmembranous receptor ALK1.
The Biomics team uses functional genomics and phenomics approaches (RNAi-based high content and throughput screening) on human cells grown in 3D (organoid, spheroids, organs on chip) to characterize new biomarkers and therapeutic targets in oncology.
We design biomaterials and surfaces to guide cell fate, mimicking the specific characteristics of natural tissues, including their biochemical and physical properties. Using stem cells and technical biomaterials, we carry out fundamental in vitro and in vivo studies.
The team develops a range of proteomics approaches as part of a broad range of biologically relevant projects. The team has considerable expertise in the fields of protein quantification by mass spectrometry and proteomics analysis of complex biological systems.
The team develops genetics and chemogenomics approaches for the identification and study of proteins and small chemicals functions in cell signalling. The team pursues both a research project which aims in the characterization of novel mechanisms of regulation of innate immune and inflammatory signals, and facilities and R&D activities at the Center for the screening for BioActive Molecules (CMBA).
Cell invasion is a regulated process that is physiologically active during embryonic morphogenesis, pregnancy, and wound healing. During cancer progression, deregulated cell invasion processes contribute to many steps of the metastatic dissemination, including cellular escape from primary tumors, intravasation into the blood and lymphatic vascular compartments and metastatic seeding in distant tissues.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.