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Tissue Biomimetism

Published on 14 February 2024



Objectives
Our goal is to engineer biomimetic surfaces to mimic some features of the natural extracellular matrices, notably their biochemical and physical properties. Using these well-controlled surfaces, we study in vitro the cellular processes guiding tissue formation, including cell signaling. Our team has an expertise in glycosaminoglycans (GAG, such as heparan sulfates, hyaluronic acid) and in bone morphogenetic proteins (BMPs), which are playing a role in a large number of physiological and pathological processes.
- The first research topic focuses on 2D platforms made of streptavidin to bind heparan sulfate, cell adhesive ligands and BMPs.
- The second research topic focuses on biomimetic films made by the layer-by-layer assembly.

Using several biophysical techniques (QCM, spectroscopic ellipsometry) that are surface-sensitive, we can precisely control the functionalization of the biomimetic surfaces and quantify molecular interactions.


Fundings
Team Fondation Recherche Medicale, ANR CODECIDE (PI Corinne ALBIGES-RIZO, IAB Grenoble), IDEX IRS (IDEX University Grenoble Alpes), SATT Bioactivecoatings, ANR PRCI GlyCON (PI E. Migliorini and A. Vortkamp)


Researchers and Technical Staff
Elisa Migliorini, CNRS Researcher - Biography
Catherine Picart, CEA Researcher - Biography
Paul Machillot, CNRS Assistant Engineer - Biography


Students
Irène Arnaldos-Perez - PhD Student
Bojana Bogdanovic ​- M2 Student
Elisa Lambert - Postdoc fellow


Selected Publications
Migliorini E, Horn P, Haraszti T, Wegner SV, Hiepen C, Knaus P, Richter RP and Cavalcanti-Adam EA
Enhanced biological activity of BMP-2 bound to surface-grafted heparan sulfate.
Advanced Biosystems, 2017, 1(4): 1600041

Thakar D, Dalonneau F, Migliorini E, Lortat-Jacob H, Boturyn D, Albiges-Rizo C, Coche-Guerente L, Picart C and Richter RP
Binding of the chemokine CXCL12a to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility.
Biomaterials, 2017, 123: 24-38

Migliorini E, Valat A, Picart C and Cavalcanti-Adam EA
Tuning cellular responses to BMP-2 with material surfaces.
Cytokine Growth Factor Reviews, 2016, 27: 43-54