This research axis aims at characterize the molecular mechanisms established by CK2 protein kinase and microRNAs to promote aggressiveness of kidney cancer and adrenocortical cancer in relation to the tumor ecosystem.
miR-483-5p | | miR-483-5p | | NDRG2 |
 | |  | |  |
Hybridation
in situ | | Hybridation in situ | | Immunohistochimie |
| | | | |
Mutations in ß-catenin in adrenocortical carcinoma lead to ß-catenin stabilization in the cytoplasm, its translocation into the nucleus then induction of its target gene expression, including miR-139-5p. MiR-139-5p is involved in the invasive phenotype of ACC and is associated with the poor prognosis of patients. miR-139-5p represses the expression of its target gene NDRG4 (N-myc Downstream Regulated Gene member 4) and thereby, promotes cell migration and invasion. | |
Detection of miR-483-5p by in situ hybridization (purple) and immunodetection of one of its target genes NDRG2 (N-myc Downstream Regulated Gene member 2, brown) in adrenocortical cancer.
Nc = normal adrenal cortex. n = nodule. Tm = tumor.
Note that overexpression of miR-483-5p in the tumor nodule or in the tumor is associated with underexpression of its target gene NDRG2 (inverse correlation).
|