Objectives We are combining 3D scaffold and 2D bioactive coating to create biomimetic cancer niches. The bioactive coatings are made using the layer-by-layer assembly. They can deliver bioactive molecules, including chemokines, hydrophobic drugs and peptides. We aim to understand how breast cancer cells respond to specific stimuli and to optimize drug treatments in cancers.
Fundings Fond Unique Interministeriel (FUI) 3D ONCOCHIP (PI CTI Biotech),
Fondation ARC pour la Recherche Contre le Cancer.
Researchers and Staff
Catherine Picart, CEA Researcher -
Biography Paul Machillot, CNRS Assistant Engineer -
Biography
Students
Nathan Thibieroz, PhD Student
Selected Publications
Liu XQ, Fourel L, Dalonneau F, Sadir R, Leal S, Lortat-Jacob H, Weidenhaupt M, Albiges-Rizo C and Picart C Biomaterials-enabled delivery of SDF-1a at the ventral side of breast cancer cells reveals a crosstalk between cell receptors and to promote the invasive phenotype.
Biomaterials, 2017,
127: 61-74
Dalonneau F, Liu XQ, Rabir R, Almodovar J, Mertani HC, Bruckert C, Mertani H, Albiges-Rizo C, Weidenhaupt M, Lortat-Jacob H and Picart C The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis.
Biomaterials, 2014,
35(15): 4525–4535
Shen L, Wang B, Wang J, Fu J, Picart C, and Ji J Asymmetric free-standing film with multifunctional anti-bacterial and self-cleaning properties.
ACS Applied Materials & Interfaces, 2012,
4(9): 4476–4483
Boudou T, Kharkar P, Jing J, Guillot R, Pignot-Paintrand I, Auzely-Velty R and Picart C Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for the delivery of Paclitaxel.
Journal of Control. Release, 2012,
159(3): 403–412
Cui D, Jing J, Boudou T, Pignot-Paintraind I, De Koker S, De Geest BG, Picart C and Auzély-Velty R Hydrophobic shell loading of biopolyelectrolyte capsules.
Advanced Materials, 2011,
23(24): H200-H204
Cui D, Anna Szarpak A, Pignot-Paintrand I, Varrot A, Boudou T, Detrembleur C, Jérôme C, Picart C and Auzély-Velty R Contact-killing polyelectrolyte microcapsules based on chitosan derivatives.
Advanced Functional Materials, 2010,
20(19): 3303-3312