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Biomaterials for cancer therapy



Published on 19 August 2020
Objectives
We are combining 3D scaffold and 2D bioactive coating to create biomimetic cancer niches. The bioactive coatings are made using the layer-by-layer assembly. They can deliver bioactive molecules, including chemokines, hydrophobic drugs and peptides. We aim to understand how breast cancer cells respond to specific stimuli and to optimize drug treatments in cancers.

Fundings
Fond Unique Interministeriel (FUI) 3D ONCOCHIP (PI CTI Biotech), Fondation ARC pour la Recherche Contre le Cancer.

Researchers and Staff
Catherine Picart, CEA Research Director - Biography
Paul Machillot, CNRS Assistant Engineer - Biography
Lauriane Bosc, CNRS, Research Engineer CDD - Biography

Students
Arunkumar Rengaraj, Post-doc Association Recherche Contre le Cancer

Selected Publications
Liu XQ, Fourel L, Dalonneau F, Sadir R, Leal S, Lortat-Jacob H, Weidenhaupt M, Albiges-Rizo C and Picart C

Biomaterials-enabled delivery of SDF-1a at the ventral side of breast cancer cells reveals a crosstalk between cell receptors and to promote the invasive phenotype.
Biomaterials, 2017, 127: 61-74

Dalonneau F, Liu XQ, Rabir R, Almodovar J, Mertani HC, Bruckert C, Mertani H, Albiges-Rizo C, Weidenhaupt M, Lortat-Jacob H and Picart C
The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis.
Biomaterials, 2014, 35(15): 4525–4535

Shen L, Wang B, Wang J, Fu J, Picart C, and Ji J
Asymmetric free-standing film with multifunctional anti-bacterial and self-cleaning properties.
ACS Applied Materials & Interfaces, 2012, 4(9): 4476–4483

Boudou T, Kharkar P, Jing J, Guillot R, Pignot-Paintrand I, Auzely-Velty R and Picart C
Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for the delivery of Paclitaxel.
Journal of Control. Release, 2012, 159(3): 403–412

Cui D, Jing J, Boudou T, Pignot-Paintraind I, De Koker S, De Geest BG, Picart C and Auzély-Velty R
Hydrophobic shell loading of biopolyelectrolyte capsules.
Advanced Materials, 2011, 23(24): H200-H204

Cui D, Anna Szarpak A, Pignot-Paintrand I, Varrot A, Boudou T, Detrembleur C, Jérôme C, Picart C and Auzély-Velty R
Contact-killing polyelectrolyte microcapsules based on chitosan derivatives.
Advanced Functional Materials, 2010, 20(19): 3303-3312