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Invasion Mechanisms in Angiogenesis and Cancer (IMAC)

Published on 26 February 2024
Team leader 
Nadia Cherradi
Tel. : 04 38 78 35 01

Laboratoire Biologie et Biotechnologies pour la Santé
17 avenue des Martyrs
38 054 Grenoble cedex 9

Members of the team

BANGOURA Mohamed - PhD Student,
BERTAL Walid - INSERM Fixed-term contract, Walid.Bertal[@]
CESANA Béatrice - PhD Student
CHABRE Olivier - MD PhD, Professor at UGA,
CHERRADI Nadia - INSERM Research Director,
COCHET Claude - INSERM Emerite Research Director,
CRISTANTE Justine - MD PhD,   University Hospital of Grenoble,
DENIS-LAMPERT Josiane - INSERM Engineer,
FANCELLO Laura - INSERM Fixed-term contract, Laura.Fancello[@]
FILHOL-COCHET Odile - INSERM Researcher,
GUYON Laurent - CEA Researcher,
KOCA Dzenis - PhD Student,
PILLET Catherine - CEA Engineer,
VELUT Louise - PhD Student,

Presentation of the team
The dissemination of cancer cells (metastasis) is the main cause of cancer-related death in humans. This process involves several steps including migration and invasion of tumor cells through various tissues and intravasation into the circulation to colonize distant organ sites. Tumor cells hijack different cellular and non-cellular non-malignant components of the tumor microenvironment to promote their own growth and survival; in return, the tumor microenvironment contributes to the migration and invasion of cancer cells. This cooperation plays a fundamental role in tumor progression and metastasis to target organs. Cell invasion is triggered by growth factors and cytokines secreted in the tumor microenvironment, by hypoxia and extracellular matrix remodeling, which activate several intracellular signaling pathways. It is well established that protein kinases and microRNAs are major players in these processes.
Our team is focused on the study of microARNs and CK2 in two highly aggressive cancers, namely adrenocortical carcinoma (ACC) and clear cell renal carcinoma (ccRCC). Both cancers share a poor prognosis and are highly metastatic.

Adrenocortical Carcinoma - Clear Cell Renal Cell Carcinoma - Protein Kinase CK2 - microRNA - Kinase inhibitors - Single cell - Diagnostic/prognostic biomarkers - Metastasis - Bioinformatics - Artificial Intelligence - Systems Biology