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Invasion Mechanisms in Angiogenesis and Cancer team (IMAC)

Published on 30 October 2020
Team leader
Nadia Cherradi
Phone: 04 38 78 35 01



Adress
Laboratoire Biologie et Biotechnologie pour la Santé
CEA-Grenoble
17 avenue des Martyrs
38 054 Grenoble cedex 9
France


Members of the team



Christophe Battail, CEA researcher 
Laurence Bouillet, PU-PH Grenoble University Hospital
Olivier Chabre, PU-PH Grenoble University Hospital
Nadia Cherradi, Inserm researcher
Claude Cochet, Inserm researcher
Justine Cristante, PhD student 
Josiane Denis, Research engineer
Odile Filhol-Cochet, Inserm researcher
Laurent Guyon, CEA researcher
Rémy Jardiller, PhD student
Catherine Pillet
, CEA engineer
Soha Reda El Sayed
, PhD student 
Irinka Seraudie
, PhD student 


Introduction
Since our previous studies have identified crucial functions for EG-VEGF, microRNA, CK2, and VE-cadherin in cell invasion process, the main objectives of our project are to pursue the characterization of the molecular and cellular mechanisms activated by these factors under both physiological and pathological conditions and to integrate these observations into a unifying model. As cell invasion relies on the interactions between several cell types, paracrine regulations and cross-talks between signaling pathways will be examined in physiological (human placentation) and pathological contexts (cancer, angiogenesis). EMT and tumor vascularization being targets of major importance in tumors, we will focus our research on these two processes. The emerging technology of heterotypic 3D cell cultures will be developed for these cell signaling studies and for anti-metastatic drug screening. Furthermore, analysis of the potential interest of the aforementioned signaling components as diagnostic and prognostic biomarkers for clinical applications will be investigated in collaboration with the clinicians of the team.