Protein kinase CK2, a theranostic biomarker

Researchers at our laboratory demonstrate that protein kinase CK2 has acquired the status of a relevant theranostics biomarker.

Published on 2 March 2011

Highlight available in French.

^[1] Prudent R, Moucadel V, Nguyen CH, Barette C, Schmidt F, Florent JC, Lafanechère L, Sautel CF, Duchemin-Pelletier E, Spreux E, Filhol O, Reiser JB and Cochet C
Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.
Cancer Research, 2010

^[2] Laramas M, Pasquier D, Filhol O, Ringeisen F, Descotes JL and Cochet C
Nuclear localization of protein kinase CK2 catalytic subunit (CK2ß) is associated with poor prognostic factors in human prostate cancer.
European Journal of Cancer, 2007

^[3] Giusiano S, Cochet C, Filhol O, Duchemin-Pelletier E, Secq V, Bonnier P, Carcopino X, Boubli L, Birnbaum D, Garcia S, Iovanna J and Charpin C
Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: Quantitative immunohistochemistry in tissue microarrays.
European Journal of Cancer, 2011

^[4] Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K and Clarke MF
The prognostic role of a gene signature from tumorigenic breast-cancer cells.
New England Journal of Medicine, 2007

^[5] Siddiqui-Jain A, Drygin D, Streiner N, Chua P, Pierre F, O'Brien SE, Bliesath J, Omori M, Huser N, Ho C, Proffitt C, Schwaebe MK, Ryckman DM, Rice WG and Anderes K
CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy.
Cancer Research, 2010

Top page

Keywords : CK2 | IMAC | biomarker

Alternative and Atomic Energies Agency

CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.

Top page

Biology and Biotechnologies for Health Laboratory

In the same section :

Protein kinase CK2, a theranostic biomarker

References

Keywords : CK2 | IMAC | biomarker

Concerning CK2

Browse the site

Alternative and Atomic Energies Agency

Browse the portal

Biology and Biotechnologies for Health Laboratory

The lab

BMP family in angiogenesis and lymphangiogenesis team (BAL)

Biomimetism and Regenerative Medicine Team (BRM)

Invasion Mechanisms in Angiogenesis and Cancer (IMAC)

Mechanisms of Angiogenesis in Biological Barriers team (MAB2)

In the same section :

Protein kinase CK2, a theranostic biomarker

References

Keywords : CK2 | IMAC | biomarker

Concerning CK2

Browse the site

Alternative and Atomic Energies Agency

Browse the portal