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Biomimetism and Regenerative Medicine Team (BRM)
Invasion Mechanisms in Angiogenesis and Cancer team (IMAC)
Mechanisms of Angiogenesis in Biological Barriers team (MAB2)
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The ALK1 receptor is no longer an orphan
We have published that two proteins, BMP9 and BMP10, are ligands of a receptor whose mutations are responsible for a rare vascular disease, the Rendu-Osler disease.
[1] Lamouille S, Mallet C, Feige JJ and Bailly S Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood, 2002 [2] David L, Mallet C, Mazerbourg S, Feige JJ and Bailly S Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) endothelial cells. Blood, 2007
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.
We have published that two proteins, BMP9 and BMP10, are ligands of a receptor whose mutations are responsible for a rare vascular disease, the Rendu-Osler disease.