​​At the 12th Worl Biomaterials Congress, Catherine Picart, head of Biomimetism and Regenerative Medicine team at Biosante will focus on two major applications of layer-by-layer films for regenerative medicine. The first concerns the development of a new type of bioactive medical device for application in bone tissue engineering to repair large bone defects in vivo. The second concerns the development of biomimetic coatings in cell culture microplates to study cell signalling using a high content approach in vitro. Such film-coated microplates enable to gain information on the respective roles of bioactive molecules, like growth factors, and of film stiffness, on cellular processes.

The presentation will show how biomimetic coatings can be used to study signaling by several proteins of the bone morphogenetic family and to reveal the key roles of BMPs, of film stiffness and of cellular receptors in stem cell adhesion and differentiation.