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Publications de l'équipe jusqu'en 2020

Publié le 29 juin 2021

Abi Nahed R, Reynaud D, Lemaitre N, Lartigue S, Roelants C, Vaiman D, Benharouga M, Cochet C, Filhol O and Alfaidy N
Protein kinase CK2 contributes to placental development: Physiological and pathological implications.
Journal of Molecular Medicine, 2020, 98(1): 123-133

Alfaidy N, Brouillet S, Rajaraman G, Kalionis B, Hoffmann P, Barjat T, Benharouga M and Murthi P
The emerging role of the prokineticins and homeobox genes in the vascularization of the placenta: Physiological and pathological aspects.
Frontiers in Physiology, 2020, 21: Article 591850

Bouzoubaa M, Benlahfid M, Sidqui M, Aboussaouira T, Rifki C, Brouillet S, Traboulsi W, Alfaidy N and Benharouga M
Vascular endothelial growth factor (VEGF) and Endocrine gland-VEGF (EG-VEGF) are down regulated in head and neck cancer.
Clinical Otolaryngology, 2020, 45(5): 788-795

Collet C, Abi Nahed R, Gemy K, Traboulsi W, Lemaitre N, Bolze PA, Hoffmann P, Benharouga M and Alfaidy N
Multifaceted functions of Prokineticins in reproductive cancers and proposed associated therapies.
Journal of Cancer Science and Clinical Therapeutics, 2020, 4(4): 408-423

Gonneaud A, Fakhir FZ, Landas E, Le Tallec E, Chartier E, Almunia C, Chenal A, Forge V and Marquette C
Development of conformational antibodies to detect Bcl-xL’s amyloid aggregates in metal-induced apoptotic neuroblastoma cells.
International Journal of Molecular Science, 2020, 21(20): 7625


Abi Nahed R, Reynaud D, Borg AJ, Traboulsi W, Wetzel A, Sapin V, Brouillet S, Dieudonné MN, Dakouane-Giudicelli M, Benharouga M, Murthi P and Alfaidy N
NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation.
Journal of Molecular Medicine, 2019, 97(3): 355-367

Alfaidy N, Baron C, Antoine Y, Reynaud D, Traboulsi W, Gueniffey A, Lamotte A, Melloul E, Dunand C, Villaret L, Bessonnat J, Mauroy C, Boueihl T, Coutton C, Martinez G, Hamamah S, Hoffmann P, Hennebicq S and Brouillet S

Prokineticin 1 is a new biomarker of human oocyte competence: Expression and hormonal regulation throughout late folliculogenesis.
Biology of Reproduction, 2019, 101(4):832-841

Hasna J, Abi Nahed R, Sergent F, Alfaidy N and Bouron A
The deletion of TRPC6 channels perturbs Iron and Zinc homeostasis and pregnancy outcome in mice.
Cellular Physiology and Biochemistry, 2019, 52(3): 455-467

Pansieri J, Josserand V, Lee S-J, Rongier A, Imbert D, Moulin Sallanon M, Kövari E, Dane T, Vendrely C, Chaix O, Guidetti M, Vollaire J, Fertin A, Yves Usson Y, Rannou P, Coll J-L, Marquette C and Forge V
UV-Vis-NIR optical properties of amyloid fibrils as a new light on amyloidogenesis.
Nature Photonics, 2019, 13: 473–479

Ranzil S, Ellery S, Walker DW, Vaillancourt C, Alfaidy N, Bonnin A, Borg A, Wallace EM, Ebeling PR, Erwich JJ andMurthi P
Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction.
Placenta, 2019, 84:74-83

Wackenheim C, Hoffman P, Dumestre-Pérard C, Bouillet L, Alfaidy N and Deroux A
Prévalence et caractéristiques de l’auto-immunité sérique chez les patientes suivies pour infertilité au CHU de Grenoble.
La Presse Médicale, 2019, 48(11 Pt 1): e307-e315


Benlahfid M, Traboulsi W, Sergent F, Benharouga M, Elhattabi K, Erguibi D, Karkouri M, Elattar H, Fadil A, Fahmi Y, Aboussaouira T and Alfaidy N
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor PROKR2 are associated to human colorectal cancer progression and peritoneal carcinomatosis.
Cancer Biomarkers, 2018, 21(2): 345-354

Berkane N, Liere P, Lefevre G, Alfaidy N, Abi Nahed R, Vincent J, Oudinet JP, Pianos A, Cambourg A, Rozenberg P, Galichon P, Rousseau A, Simon T, Schumacher M, Chabbert-Buffet N and Hertig A
Abnormal steroidogenesis and aromatase activity in preeclampsia.
Placenta, 2018, 69: 40-9

Lappas M, McCracken S, McKelvey K, Lim R, James J, Roberts CT, Fournier T, Alfaidy N, Powell KL, Borg AJ, Morris JM, Leaw B, Singh H, Ebeling PR, Wallace EM, Parry LJ, Dimitriadis E and Murthi P
Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.
Molecular Human Reproduction, 2018, 24(2): 94-109

Pansieri J, Gerstenmayer M, Lux F, Mériaux S, Tillement O, Forge V, Larrat B and Marquette C
Magnetic nanoparticles applications for amyloidosis study and detection: A review.
Nanomaterials, 2018, 8(9): Article number 0740

Pansieri J, Halim MA, Vendrely C, Dumoulin M, Legrand F, Sallanon MM, Chierici S, Denti S, Dagany X, Dugourd P, Marquette C, Antoine R and Forge V
Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: Mapping heterogeneity and polymorphism.
Chemical Science, 2018, 9(10): 2791-2796

Reynaud D, Sergent F, Abi Nahed R, Brouillet S, Benharouga M and Alfaidy N
EG-VEGF maintenance over early gestation to develop a pregnancy-induced hypertensive animal model.
Methods in Molecular Biology, 2018, 1710: 317-324


Abi Nahed R, Reynaud D, Traboulsi W, Ndagijimana S, Dieudonné MN, Hoffmann P, Benharouga M and Alfaidy N
NLRP7 inflammasome is activated in FGR pregnancies: Physiological and physio-pathological implications.
Placenta, 2017, 57(Supplement C): 287

Pansieri J, Plissonneau M, Stransky-Heilkron N, Dumoulin M, Heinrich-Balard L, Rivory P, Morfin JF, Toth E, Saraiva MJ, Allémann E, Tillement O, Forge V, Lux F and Marquette C
Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.
Nanomedecine, 2017, 12(14): 1675-1687

Traboulsi W, Sergent F, Boufettal H, Brouillet S, Slim R, Hoffmann P, Benlahfid M, Zhou QY, Balboni G, Onnis V, Bolze PA, Salomon A, Sauthier P, Mallet F, Aboussaouira T, Feige JJ, Benharouga M and Alfaidy N
Antagonism of EG-VEGF receptors as targeted therapy for Choriocarcinoma progression in vitro and in vivo.
Clinical Cancer Research, 2017, 23(22): 7130-7140


Alfaidy N
Prokineticin1 and pregnancy.
Annales d'Endocrinologie, 2016, 77(2): 101-104

Alfaidy N, Hoffmann P, Gillois P, Gueniffey A, Lebayle C, Garçin H, Thomas-Cadi C, Bessonnat J, Coutton C, Villaret L, Quenard N, Bergues U, Feige JJ, Hennebicq S and Brouillet S
PROK1 level in the follicular microenvironment: A new noninvasive predictive biomarker of embryo implantation.
Journal of Clinical Endocrinology and Metabolism, 2016, 101(2): 435-444

Plissonneau M, Pansieri J, Heinrich-Balard L, Morfin JF, Stransky-Heilkron N, Rivory P, Mowat P, Dumoulin M, Cohen R, Allémann, Tóth, Saraiva MJ, Louis C, Tillement O, Forge V, Lux F and Marquette C
Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.
Journal of Nanobiotechnology, 2016, 14(1): Article number 60

Sergent F, Hoffmann P, Brouillet S, Garnier V, Salomon A, Murthi P, Benharouga M, Feige JJ and Alfaidy N
Sustained endocrine gland-derived vascular endothelial growth factor levels beyond the first trimester of pregnancy display phenotypic and functional changes associated with the pathogenesis of pregnancy-induced hypertension.
Hypertension, 2016, 68(1): 148-156


Bardin N, Murthi P and Alfaidy N
Normal and pathological placental angiogenesis.
BioMed Research International, 2015, Article ID 354359

Chauvet S, Traboulsi W, Thevenon L, Kouadri A, Feige JJ, Camara B, Alfaidy N and Benharouga M
EG-VEGF, BV8 and their receptors expression in human bronchi and their modification in cystic fibrosis: Impact of CFTR mutation (delF508).
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2015, 309(3): L314-L322

Dakouane-Giudicelli M, Brouillet S, Traboulsi W, Torre A, Vallat G, Si Nacer S, Vallée M, Feige JJ, Alfaidy N and de Mazancourt P
Inhibition of human placental endothelial cell proliferation and angiogenesis by netrin-4.
Placenta, 2015, 36(11): 1260-1265

Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ and Alfaidy N
PPARgammacontrols pregnancy outcome through activation of EG-VEGF: New insights into the mechanism of placental development.
American Journal of Physiology. Endocrinology and Metabolism, 2015, 309(4): E357-E369

Micoud J, Chauvet S, Ludwig Scheckenbach KE, Alfaidy N, Chanson M and Benharouga M
Involvement of the heterodimeric interface region of the nucleotide binding domain-2 (NBD2) in the CFTR quaternary structure and membrane stability.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015, 1853(10 Pt A): 2420–2431

Murthi P, Brouillet S, Pratt A, Borg A, Kalionis B, Goffin F, Tsatsaris V, Munaut C, Feige J, Benharouga M, Fournier T and Alfaidy N
An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction.
Molecular Medicine, 2015, 21: 645-656
Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, Hoffmann P, Feige JJ, Benharouga M and Alfaidy N
Prokineticins in central and peripheral control of human reproduction.
Hormone Molecular Biology and Clinical Investigation, 2015, 24(2): 73-81

Wong MK, Barra NG, Alfaidy N, Hardy DB and Holloway AC
Prenatal nicotine exposure and postnatal health outcomes.
Reproduction, 2015, 150(6): R185-R193


Alfaidy N
Placenta : glande endocrine, cas de l’endocrine gland derived endothelial growth factor (EG-VEGF).
Annales d'Endocrinologie, 2014, 75(5–6): 254-255

Alfaidy N, Hoffmann P, Boufettal H, Samouh N, Aboussaouira T, Benharouga M, Feige JJ and Brouillet S
The multiple roles of EG-VEGF/PROK1 in normal and pathological placental angiogenesis.
BioMed Research International, 2014, 2014: 451906

Brouillet S, Dufour A, Prot F, Feige JJ, Equy V, Alfaidy N, Gillois P and Hoffmann P
Influence of the umbilical cord insertion site on the optimal individual birth weight achievement.
BioMed Research International, 2014, 2014: n°341251

Brouillet S, Hoffmann P, Alfaidy N and Feige JJ
[Prokineticins: New regulatory peptides in human reproduction].
Medecine Science (Paris), 2014, 30(3): 274-279

Dakouane-Giudicelli M, Alfaidy N and de Mazancourt P
Netrins and their roles in placental angiogenesis.
BioMed Research International, 2014, 2014: ID 901941

Dunand C, Hoffmann P, Sapin V, Blanchon L, Salomon A, Sergent F, Benharouga M, Sabra S, Guibourdenche J, Lye SJ, Feige JJ and Alfaidy N
Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition.
Biology of Reproduction, 2014, 91(3): 73

Holloway AC, Salomon A, Soares MJ, Garnier V, Raha S, Sergent F, Nicholson CJ, Feige JJ, Benharouga M and Alfaidy N
Characterization of the adverse effects of nicotine on placental development: In vivo and in vitro studies.
American Journal of Physiology. Endocrinology and Metabolism, 2014, 306(4): E443-456

Keramidas M, Lavaud J, Sergent F, Hoffmann P, Brouillet S, Feige JJ, Coll JL and Alfaidy N
Noninvasive and quantitative assessment of in vivo fetomaternal interface angiogenesis using RGD-based fluorescence.
BioMed Research International, 2014, 2014: 309082

Vittet D, Brouillet S, Hoffmann P, Alfaidy N and Feige JJ
Cultures de cellules endothéliales. Applications à l’étude de l’angiogenèse In Culture de cellules animales, edited by Barlovatz-Meimon G and Ronot X, Editions Inserm, 2014


Alfaidy N, Chauvet S, Andrei S, Salomon A, Saoudi Y, Richaud PR, Aude-Garcia C, Hoffmann P, Andrieux A, Moulis JM, Feige JJ and Benharouga M
Prion protein expression and functional importance in developmental angiogenesis: Role in oxidative stress and copper homeostasis.
Antioxidants and Redox Signaling, 2013, 18(4): 400-411

Boufettal H, Feige JJ, Benharouga M, Aboussaouira T, Nadifi S, Mahdaoui S, Samouh N and Alfaidy N
Rôle potentiel du facteur angiogénique « EG-VEGF » dans les maladies gestationnelles trophoblastiques.
Pathologie Biologie, 2013, 61(5): 178-183

Brouillet S, Hoffmann P, Thomas-Cadi C, Bergues U, Feige JJ, Alfaidy N and Hennebicq S
PROK1, biomarqueur de l’implantation embryonnaire ?
[PROK1, prognostic marker of embryo implantation?].
Gynécologie, Obstétrique & Fertilité, 2013, 41(9): 562-565

Brouillet S, Murthi P, Hoffmann P, Salomon A, Sergent F, De Mazancourt P, Dakouane-Giudicelli M, Dieudonné MN, Rozenberg P, Vaiman D, Barbaux S, Benharouga M, Feige JJ and Alfaidy N
EG-VEGF controls placental growth and survival in normal and pathological pregnancies: Case of fetal growth restriction (FGR).
Cellular and Molecular Life Sciences, 2013, 70(3): 511-525

Faure C, Hoffmann P, Salomon A, Garnier V, Sapin V, Blanchon L, Guibourdenche J, Benharouga M, Feige JJ and Alfaidy N
Membranes fœtales humaines, nouvelles sources et cibles du facteur endocrine EG-VEGF : implications physiologiques et physiopathologiques.
Annales d'Endocrinologie, 2013, 74(4): 312

Garnier V, Salomon A, Fournier T, Sergent F, Hoffmann P, Feige JJ and Alfaidy N
Contribution à la compréhension du mécanisme de régulation de l’invasion trophoblastique par PPARgamma : implication de l’EG-VEGF.
Annales d'Endocrinologie, 2013, 74(4): 262

Holloway A, Salomon A, Raha S, Granier V, Sergent MF, Nicholson CJ, Feige JJ, Benharouga M and Alfaidy N
Effet de l’exposition à la nicotine sur le développement placentaire : étude in vivo et in vitro.
Annales d'Endocrinologie, 2013, 74(4): 262-263

Kaspi E, Guillet B, Piercecchi-Marti MD, Alfaidy N, Bretelle F, Bertaud-Foucault A, Stalin J, Rambeloson L, Lacroix O, Blot-Chabaud M, Dignat-George F and Bardin N
Identification of soluble CD146 as a regulator of trophoblast migration: Potential role in placental vascular development.
Angiogenesis, 2013, 16(2): 329-342

Keramidas M, Josserand V, Feige JJ and Coll JL
Noninvasive and quantitative assessment of in vivo angiogenesis using RGD-based fluorescence imaging of subcutaneous sponges.
Molecular Imaging and Biology, 2013, 15(3): 239-244


Brouillet S, Hoffmann P, Chauvet S, Salomon A, Chamboredon S, Sergent F, Benharouga M, Feige JJ and Alfaidy N
Revisiting the role of hCG: New regulation of the angiogenic factor EG-VEGF and of its receptors.
Cellular and Molecular Life Sciences, 2012, 69(9): 1537-1550

Brouillet S, Hoffmann P, Feige JJ and Alfaidy N
EG-VEGF: A key endocrine factor in placental development.
Trends in Endocrinology and Metabolism, 2012, 23(10): 501–508

Hoffmann P, Brouillet S, Benharouga M, Feige JJ and Alfaidy N
Role of EG-VEGF in human placentation: Physiological and pathological implications In Recent Advances In Research on The Human Placenta, Edited by Zheng J, InTech, 2012, Chap 14, pp 287-306

Chenal A, Vendrely C, Vitrac H, Karst JC, Gonneaud A, Blanchet CE, Pichard S, Garcia E, Salin B, Catty P, Gillet D, Hussy N, Marquette C, Almunia C and Forge V
Amyloid fibrils formed by the programmed cell death regulator Bcl-xL.
Journal of Molecular Biology, 2012, 415(3): 584-599


Bouillot S, Tillet E, Carmona G, Prandini MH, Gauchez AS, Hoffmann P, Alfaidy N, Cand F and Huber P
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: EVIDENCE OF SHEDDING UP-REGULATION IN PRE-ECLAMPSIA.
Journal of Biological Chemistry, 2011, 286(17): 15195-15204

Dakouane-Giudicelli M, Alfaidy N, Bayle P, Tassin de Nonneville A, Studer V, Rozenberg P and de Mazancourt P
Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of Netrin-1, in first trimester human placenta.
International Journal of Developmental Biology, 2011, 55(10-12): 981-987


Benaitreau D, Dos Santos E, Leneveu MC, Alfaidy N, Feige JJ, Demazancourt P, Pecquery R and Dieudonne MN
Effects of adiponectin on human trophoblast invasion.
Journal of Endocrinology, 2010, 207(1): 45-53

Brouillet S, Hoffmann P, Benharouga M, Salomon A, Schaal JP, Feige JJ and Alfaidy N
Molecular characterization of EG-VEGF-mediated angiogenesis: Differential effects on microvascular and macrovascular endothelial Cells.
Molecular Biology of the Cell, 2010, 21(16): 2832-2843

Unlugedik E, Alfaidy N, Holloway A, Lye S, Bocking A, Challis J and Gibb W
Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm.
Reproduction Fertility and Developement, 2010, 22(5): 796-807


Brouillet S, Hoffmann P, Benharouga M, Feige JJ and Alfaidy N
EG-VEGF is a new angiogenic factor in human placenta: Effects on micro and macrovascular endothelial cells.
Reproductive Sciences, 2009, 16: 2

Brouillet S, Hoffmann P, Chamboredon S, Feige JJ and Alfaidy N
Human chorionic gonadotropin (hCG) up-regulates EG-VEGF, PKR1 and PKR2 expression in human placenta: A new physiological loop of regulation.
Reproductive Sciences, 2009, 16: 305

Hoffmann P, Saoudi Y, Benharouga M, Graham CH, Schaal JP, Mazouni C, Feige JJ and Alfaidy N
Role of EG-VEGF in human placentation: Physiological and pathological implications.
Journal of Cellular and Molecular Medicine, 2009, 13(8b): 2224-2235

Marquette C, Mathieu J, Bertho JM, Galonnier M, Wysoki J, Maubert C, Balanzat E, Gerbin R, Aigueperse J and Clarencon D
Neuroimmune response and sleep studies after whole body irradiation with high-LET particles.
Advances in Space Research, 2009, 44(8): 934-941

Petrik JJ, Gerstein HC, Cesta CE, Kellenberger LD, Alfaidy N and Holloway AC
Effects of rosiglitazone on ovarian function and fertility in animals with reduced fertility following fetal and neonatal exposure to nicotine.
Endocrine, 2009, 36(2): 281-290


Donadio S, Alfaidy N, De Keukeleire B, Micoud J, Feige JJ, Challis JR and Benharouga M
Expression and localization of cellular prion and COMMD1 proteins in human placenta throughout pregnancy.
Placenta, 2007, 28(8-9): 907-911

Hoffmann P, Feige JJ and Alfaidy N
Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.
Placenta, 2007, 28(10): 1049-1058


Dublineau I, Grison S, Linard C, Baudelin C, Dudoignon N, Souidi M, Marquette C., Paquet F, Aigueperse J, Gourmelon P
Short-term effects of depleted uranium on immune status in rat intestine.
J Toxicol Environ Health A. 2006, 69(17): 1613-1628

Gueguen Y, Souidi M, Baudelin C, Dudoignon N, Grison S, Dublineau I, Marquette C., Voisin P, Gourmelon P and Aigueperse J
Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat.
Archives of Toxicology, 2006, 80(4): 187-195

Hoffmann P, Feige JJ and Alfaidy N
Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy.
Endocrinology, 2006, 147(4): 1675-1684

Podlovni H, Ovadia O, Kisliouk T, Klipper E, Zhou QY, Friedman A, Alfaidy N and Meidan R
Differential expression of prokineticin receptors by endothelial cells derived from different vascular beds: A physiological basis for distinct endothelial function.
Cellular Physiology and Biochemistry, 2006, 18(6): 315-326