Biology and Biotechnologies for Health Laboratory - UMR_S 1292 CEA/Inserm/UGA - Other news https://biosante-lab.fr/en/Pages/Theses.aspx en-US https://biosante-lab.fr/en/SiteAssets/min_logo_Biosante.png Biology and Biotechnologies for Health Laboratory - UMR_S 1292 CEA/Inserm/UGA - Other news https://biosante-lab.fr/en Functions of the ALK1 receptor in the adult endothelium: Toward New Therapies for Rendu-Osler Disease https://biosante-lab.fr/en/Pages/Theses/2025/Yasmin-Rida.aspx Thesis defended on November 18, 2025, by Yasmin Rida to obtain a doctorate from the University of Grenoble Alpes - Specialization: Physiology-Physiopathology-Pharmacology. BAL;PhD defense;Rendu-Osler;endothelial cells;liver;ALK1; Tue, 18 Nov 2025 11:00:00 GMT Identification of sensitive and specific biomarkers for the prediction of the survival of patients with cancer https://biosante-lab.fr/en/Pages/Theses/2025/Dzenis-Koca.aspx Thesis defended on November 6, 2025, by Dzenis KOCA to obtain a doctorate from the University of Grenoble Alpes PhD defense;renal cancer;COL7A1;IMAC; Thu, 06 Nov 2025 11:00:00 GMT Biomaterials for regenerative medicine of mesenchymal stem cells https://biosante-lab.fr/en/Pages/Theses/2025/Irene-Arnaldos.aspx Thesis defended on October 8, 2025, by Irene ARNALDOS PÉREZ to obtain a doctorate from the University of Grenoble Alpes - Specialization: BIS - Biotechnology, Instrumentation, Signals, and Imaging for Biology, Medicine, and the Environment. BRM;BMP;PhD defense;regenerative medicine;biophysics;Leukemia; Wed, 08 Oct 2025 10:00:00 GMT Pulmonary Inflammation in Cystic Fibrosis: Functional Roles of CFTR and PROK1 in Epithelial and Endothelial Barrier Disruption https://biosante-lab.fr/en/Pages/Theses/2025/Camille-Lyko.aspx Thesis defended on October 3, 2025, by Camille LYKO to obtain a doctorate from the University of Grenoble Alpes - Specialization: Physiology-Physiopathology-Pharmacology. MAB2;PhD defense;cystic fibrosis;lung;Inflammation;CFTR; Fri, 03 Oct 2025 10:00:00 GMT Analysis of single-cell microRNA-mRNA co-sequencing data and comparison of microRNA target prediction algorithms https://biosante-lab.fr/en/Pages/Theses/2025/Louise-Velut.aspx Thesis defended on October 2, 2025 by Louise VELUT to obtain a doctorate from the University of Grenoble Alpes - Specialization: MBS - Models, methods, and algorithms in biology, health, and the environment. IMAC;PhD defense;microRNA targets;single cell;sequencing;microRNA; Thu, 02 Oct 2025 10:00:00 GMT Role of PROK1 in the diagnosis and the treatment of infection-related preterm birth https://biosante-lab.fr/en/Pages/Theses/2025/Morgane-Desseux.aspx Thesis defended on September 25, 2025, by Morgane Desseux to obtain a doctorate from the University of Grenoble Alpes - Specialization: Cell Biology. PROK1;MAB2;PhD defense;biomarker;pregnancy; Thu, 25 Sep 2025 10:00:00 GMT Metastatic Renal Cancer: Toward a Microfluidic Chip Model to Study Intravasation and Tropism for a Bone Metastatic Niche https://biosante-lab.fr/en/Pages/Theses/2025/Beatrice-Cesana.aspx Thesis defended on September 17, 2025, by Beatrice Cesana to obtain a doctorate from the University of Grenoble Alpes - Specialization: Cell Biology. IMAC;PhD defense;kidney cancer;Medical device;tumoroid;microfluidic device; Wed, 17 Sep 2025 10:00:00 GMT Characterization of the role of prokineticins during perinatal infection: Impact on the placenta and the fetal brain https://biosante-lab.fr/en/Pages/Theses/2024/Margaux-Digonnet_uk.aspx Thesis presented October 4, 2024 by Margaux Digonnet. MAB2;PhD defense;PROK1;ProK2;EG-VEGF; Fri, 04 Oct 2024 10:00:00 GMT Biophysical analysis of extracellular vesicles for diagnostics and precision medicine https://biosante-lab.fr/en/Pages/Theses/2023/Katell-Aldrin.aspx Thesis presented December 20, 2023 by Katell Aldrin. IMAC;microfluidics;PhD defense;extracellular vesicles; Wed, 20 Dec 2023 11:00:00 GMT Deciphering early phosphoproteome changes in response to BMP9 and BMP10 in endothelial cells https://biosante-lab.fr/en/Pages/Theses/2023/Mohammad-Al-Tarrass.aspx Thesis presented October 24, 2023 by Mohammad Al Tarrass. PhD thesis available as a pdf file. ALK;BAL;ALK1;HHT;PhD defense;phosphoproteome;PAH; Tue, 24 Oct 2023 10:00:00 GMT Biomimetic approach to decipher the mechanisms by which glycosaminoglycans regulate bone morphogenetic protein 2 (BMP2) signaling https://biosante-lab.fr/en/Pages/Theses/2023/Jean-le-Pennec.aspx Thesis presented October 20, 2023 by Jean le Pennec. GAG;BMP2;biomimétisme;BRM;PhD defense;Signaling;Glycosaminoglycans;biomimetics; Fri, 20 Oct 2023 10:00:00 GMT Effect of Prokineticins on the brain in the context of Preeclampsia https://biosante-lab.fr/en/Pages/Theses/2023/Hadi-Younes.aspx Thesis presented September 21, 2023 by Hadi Younes. MAB2;PROKR1;PROKR2;PROK1;PhD defense;preeclampsia;pregnancy;prokineticins; Thu, 21 Sep 2023 10:00:00 GMT Transcriptomic characterization of endothelial cells from HHT and PAH patients carrying ALK1 mutations to propose new therapeutic approaches for these two vascular diseases https://biosante-lab.fr/en/Pages/Theses/2023/Tala-Al-Tabosh.aspx Thesis presented May 31, 2023by Tala Al Tabosh. PhD thesis available as a pdf file. BMP10;ALK;BMP9;BAL;ALK1;HHT;PhD defense;transcriptomics;Angiogenesis;PAH; Wed, 31 May 2023 10:00:00 GMT Characterization of the role of prokineticins in high-grade serous ovarian carcinoma https://biosante-lab.fr/en/Pages/Theses/2023/Constance-Collet.aspx Thèse soutenue le 27 mars 2023 par Constance Collet pour obtenir le grade de docteur de la Communauté Université Grenoble Alpes - Spécialité : Biologie du développement - Oncogenèse. HGSOC;ProK2;PROKR2;PROKR1;PROK1;PhD defense;MAB2; Mon, 27 Mar 2023 10:00:00 GMT Biochemical and cellular characterization of PROKR1 and PROKR2 receptors and structural screening of their ligand PROK1: Interest for PROK1-dependent pathologies https://biosante-lab.fr/en/Pages/Theses/2023/Kevin-Gemy.aspx Thesis presented March 24, 2023 by Kévin Gemy. PhD thesis available as a pdf file. MAB2;EG-VEGF;PROKR2;PROKR1;PROK1;placenta;PhD defense;Choriocarcinoma; Fri, 24 Mar 2023 11:00:00 GMT Metastatic kidney cancer: Study of the mechanistics of a targeted combinational therapy and development of avatars for personalized medicine https://biosante-lab.fr/en/Pages/Theses/2023/Irinka-Seraudie.aspx Thesis presented February 20, 2023 by Irinka Seraudie. PhD thesis available as a pdf file. ROS;CRCC;CK2;IMAC;ATM;PhD defense;kidney cancer;organoids;tumoroid;Apoptosis; Mon, 20 Feb 2023 11:00:00 GMT Bioactive medical devices for bone regeneration https://biosante-lab.fr/en/Pages/Theses/2022/Charlotte-Garot.aspx Thesis presented December 08, 2022 by Charlotte Garot. BRM;PhD defense;biomaterials;bone tissue;3D printing; Thu, 08 Dec 2022 11:00:00 GMT Impact of activation of the Wnt/Beta-Catenin signaling pathway on the expression of microRNAs in adrenocortical carcinoma https://biosante-lab.fr/en/Pages/Theses/2022/Justine-Cristante.aspx Thesis presented November 10, 2022 by Justine Cristante. PhD thesis available as a pdf file. miR-139-5p;pronostique;IMAC;PhD defense;Adrenocortical carcinoma;prognosis;miRNA; Thu, 10 Nov 2022 11:00:00 GMT Deciphering the vascular functions of Bone Morphogenetic Protein 9 and 10 using knock-out mouse models https://biosante-lab.fr/en/Pages/Theses/2022/Martina-Rossi.aspx Thesis presented November 09, 2022 by Martina Rossi. BMP10;BAL;BMP9;Angiogenesis;vascular functions;PhD defense; Wed, 09 Nov 2022 11:00:00 GMT Development of an anti-cancer strategy for adrenocortical carcinoma by nanovectorization of microRNAs via Lipidots® https://biosante-lab.fr/en/Pages/Theses/2022/Soha-Reda-El-Sayed.aspx Thesis presented March 25, 2022 by Soha Reda El Sayed. PhD thesis available as a pdf file. miR-483-5p;miR-139-5p;IMAC;miRNA;Adrenocortical carcinoma;PhD defense; Fri, 25 Mar 2022 11:00:00 GMT Engineered biomimetic platforms to analyze the molecular and cellular role of heparan sulfate on BMP2 bioactivity https://biosante-lab.fr/en/Pages/Theses/2021/Julius-Sefkow-Werner.aspx Thesis presented December 15, 2021 by Julius Sefkow-Werner. PhD thesis available as a pdf file. BMP2;BRM;biomimetics;integrins;heparan sulfate;PhD defense; Wed, 15 Dec 2021 11:00:00 GMT Initial molecular steps of bone regeneration: Cellular scale modulation https://biosante-lab.fr/en/Pages/Theses/2021/Valia-Khodr.aspx Thesis presented December 06, 2021 by Valia Khodr. PhD thesis available as a pdf file. BRM;BMP;bone regeneration;PhD defense;biomaterials; Mon, 06 Dec 2021 11:00:00 GMT Epidemiological study of two pathologies of the female genital tract: preeclampsia and ovarian cancer; and molecular characterization of a common target in these two pathologies, the angiogenic factor, EG-VEGF and its receptors https://biosante-lab.fr/en/Pages/Theses/2021/Meriem-Benfateh.aspx Thesis presented July 29, 2021. MAB2;EG-VEGF;Angiogenesis;Ovarian Cancer;preeclampsia;PhD defense; Thu, 29 Jul 2021 10:00:00 GMT Evaluation of different variants of the Cox model for cancer patients prognosis from public sequencing and clinical data https://biosante-lab.fr/en/Pages/Theses/2020/Remy-Jardillier.aspx Thesis presented December 01, 2020 by Rémy Jardillier. PhD thesis available as a pdf file. IMAC;PhD defense; Tue, 01 Dec 2020 11:00:00 GMT Towards a therapy for two rare vascular diseases https://biosante-lab.fr/en/Pages/Theses/2019/Florian-Robert.aspx Thesis presented November 22, 2019 by Florian Robert. PhD thesis available as a pdf file. Rendu-Osler;ALK;BAL;hypertension;BMP9;PhD defense; Fri, 22 Nov 2019 11:00:00 GMT Role of NLRP7 protein in normal and tumor pregnancies https://biosante-lab.fr/en/Pages/Theses/2018/Deborah-Reynaud.aspx Thesis presented December 21, 2018 by Déborah Reynaud. PhD thesis available as a pdf file. Choriocarcinoma;NLRP7;PhD defense;MAB2; Fri, 21 Dec 2018 11:00:00 GMT Applications in Bioinformatics with Markov Models https://biosante-lab.fr/en/Pages/Theses/2018/Sean-Robinson.aspx Thesis presented June 1st, 2018 by Sean Robinson. PhD thesis available as a pdf file. PhD defense;IMAC; Fri, 01 Jun 2018 10:00:00 GMT ALK1: A new pathway in physiological and tumoral vascular development https://biosante-lab.fr/en/Pages/Theses/2017/Marie-Ouarne.aspx Thesis presented on November 16, 2017 by Marie Ouarné. PhD thesis available as a pdf file. ALK;BMP;BAL;Angiogenesis;lymphangiogenesis;PhD defense; Thu, 16 Nov 2017 11:00:00 GMT Role of EG-VEGF (Endocrine Gland-Derived Vascular Endothelial Growth Factor) in the development and progression of placental tumors: The case of choriocarcinoma https://biosante-lab.fr/en/Pages/Theses/2016/Wael-Traboulsi.aspx Thesis presented on December 12, 2016 by Wael Traboulsi. PhD thesis available as a pdf file. EG-VEGF;Choriocarcinoma;VE-cadherin;PhD defense;MAB2; Mon, 12 Dec 2016 11:00:00 GMT Protein kinases and renal carcinoma: Discovery and validation of a novel combinational target therapy through co-inhibition of CK2 and ATM kinases https://biosante-lab.fr/en/Pages/Theses/2016/Sofia-Giacosa.aspx Thesis presented October 14, 2016 by Sofia Giacosa. PhD thesis available as a pdf file. screening;spheroid;renal cancer;siRNA;3D culture;pharmacology;CK2;IMAC;PhD defense; Fri, 14 Oct 2016 10:00:00 GMT A novel multi-target cancer therapy based on destabilization of short-lived mRNAs https://biosante-lab.fr/en/Pages/Theses/2014/Felicitas-Rataj.aspx Thesis presented December​ 12, 2014 by Felicitas Rataj. PhD thesis available as a pdf file. Tis11B;IMAC;VEGF;Angiogenesis;mRNA;PhD defense;cancer therapy; Fri, 12 Dec 2014 11:00:00 GMT Inhibition of tumor angiogenesis: Screening of a chemical library and characterization of a new compound that targets the Ras-ERK signaling pathway https://biosante-lab.fr/en/Pages/Theses/2014/Agnes-Desroches-Castan.aspx Thesis presented October 03, 2014 by Agnès Desroches-Castan. PhD thesis available as a pdf file. VEGF;Angiogenesis;PhD defense;pharmacology;endothelial cells; Fri, 03 Oct 2014 10:00:00 GMT Role of the pro-angiogenic factor EG-VEGF in placental development during the first trimester of pregnancy https://biosante-lab.fr/en/Pages/Theses/2014/Vanessa-Garnier.aspx Thesis presented September 22, 2014 by Vanessa Garnier. PhD thesis available as a pdf file. EG-VEGF;Angiogenesis;IUGR;preeclampsia;PhD defense;pregnancy;MAB2; Mon, 22 Sep 2014 10:00:00 GMT BMP9 and BMP10 in perinatal vascular remodeling: lymphatic development, postnatal retinal angiogenesis, closure of the ductus arteriosus and gestation. Phenotypic study of the Bmp9-KO mouse https://biosante-lab.fr/en/Pages/Theses/2013/Sandrine-Levet.aspx Thesis presented October​ 02, 2013 by Sandrine Levet. PhD thesis available as a pdf file. BMP10;BMP;BMP9;BAL;Rendu-Osler;PhD defense;lymphatic vascular system; Wed, 02 Oct 2013 10:00:00 GMT Characterization of BMP9 (Bone Morphogenetic Protein 9), a new biomarker of angiogenesis? https://biosante-lab.fr/en/Pages/Theses/2012/Marie-Bidart.aspx Thesis presented October 11, 2012 by Marie Bidart. ALK;BAL;BMP9;Angiogenesis;PhD defense;biomarker;cancer therapy; Thu, 11 Oct 2012 10:00:00 GMT Dynamic of adherens junction: EPLINs' role in stabilization of intercellular contacts in the vascular endothelium https://biosante-lab.fr/en/Pages/Theses/2011/Adeline-Chervin-Petinot.aspx Thesis presented October 07, 2011 by Adeline Chervin-Pétinot. PhD thesis available as a pdf file. EPLIN;vascular endothelium;PhD defense;intercellular junctions;VE-cadherin; Fri, 07 Oct 2011 10:00:00 GMT ALK1 and BMP9 in the vascular remodeling: From human genetics to mouse models https://biosante-lab.fr/en/Pages/Theses/2011/Nicolas-Ricard.aspx Thesis presented September​ 23, 2011 by Nicolas Ricard. PhD thesis available as a pdf file. Rendu-Osler;ALK;BAL;BMP9;remodelage vasculaire;PhD defense;Angiogenesis;vascular remodeling; Fri, 23 Sep 2011 10:00:00 GMT Regulation of SNAIL1 transcription factor during Epithelial-Mesenchymal Transition in MCF10A mammary cells: Involvement of protein-kinase CK2 https://biosante-lab.fr/en/Pages/Theses/2010/Alexandre-Deshiere.aspx Thesis presented November 09, 2010 by Alexandre Deshière. PhD thesis available as a pdf file. EMT;CK2;IMAC;siRNA;PhD defense; Tue, 09 Nov 2010 11:00:00 GMT Differential properties of N- and VE-cadherin in vascular endothelium https://biosante-lab.fr/en/Pages/Theses/2010/Alice-Gentil-Dit-Maurin.aspx Thesis presented July 02, 2010 by Alice Gentil Dit Maurin. PhD thesis available as a pdf file. Angiogenesis;endothelial cells;PhD defense;VE-cadherin; Fri, 02 Jul 2010 10:00:00 GMT Identification and characterization of protein kinase CK2 inhibitors https://biosante-lab.fr/en/Pages/Theses/2009/Renaud-Prudent.aspx Thesis presented November 23, 2009 by Renaud Prudent. CK2;IMAC;pharmacology;screening;PhD defense;inhibitor peptide; Mon, 23 Nov 2009 11:00:00 GMT Insights into the role of genetic alterations in adrenocortical tumorigenesis https://biosante-lab.fr/en/Pages/Theses/2008/Maryline-Herbet.aspx Thesis presented November 21, 2008 by Maryline Herbet. PhD thesis available as a pdf file. PhD defense;adrenocortical tumorigenesis; Fri, 21 Nov 2008 11:00:00 GMT Protein transduction domain-mediated intracellular delivery of the TTP family member TIS11b/BRF1 downregulates VEGF expression in vitro and in vivo https://biosante-lab.fr/en/Pages/Theses/2008/Severine-Planel.aspx Thesis presented November 17, 2008 by Séverine Planel. PhD thesis available as a pdf file. VEGF;Tis11B;IMAC;adrenocortical tumorigenesis;PhD defense;zinc fingers;cancer therapy; Mon, 17 Nov 2008 11:00:00 GMT Identification of ALK1 ligand (activin receptor like kinase 1): BMP9. A new circulating regulator of the endothelial quiescence https://biosante-lab.fr/en/Pages/Theses/2007/Laurent-David.aspx Thesis presented October 31, 2007 by Laurent David. BMP10;ALK;BAL;PhD defense;endothelial cells;Angiogenesis;BMP;BMP9; Wed, 31 Oct 2007 11:00:00 GMT Functional study of the regulating subunit of the protein kinase CK2 in murin embryonic stem cells: Cellular survival, oligodendrogenesis and cancerogenesis https://biosante-lab.fr/en/Pages/Theses/2007/Lea-Ziercher.aspx Thesis presented October 11, 2007 by Léa Ziercher. PhD thesis available as a pdf file. CK2;IMAC;PhD defense;stem cell; Thu, 11 Oct 2007 10:00:00 GMT New architecture of the endothelial adherens junction https://biosante-lab.fr/en/Pages/Theses/2007/Stephanie-Heyraud.aspx Thesis presented October 08, 2007 by Stéphanie Heyraud. PhD thesis available as a pdf file. PhD defense;VE-cadherin;actin;endothelial junctions;moesin;annexin 2; Mon, 08 Oct 2007 10:00:00 GMT Strategies for inhibiting high affinity protein-protein interaction: Example of CK2 https://biosante-lab.fr/en/Pages/Theses/2007/Beatrice-Laudet.aspx Thesis presented October 05, 2007 by Béatrice Laudet. PhD thesis available as a pdf file. CK2;IMAC;PhD defense;pharmacology; Fri, 05 Oct 2007 10:00:00 GMT Biological functions of EGF-VEGF (Endocrine Gland-Derived Vascular Endothelial Growth Factor) in placental development https://biosante-lab.fr/en/Pages/Theses/2006/Pascale-Hoffmann.aspx Thesis presented December 15, 2006 by Pascale Hoffmann. PhD thesis available as a pdf file. EG-VEGF;Angiogenesis;IUGR;preeclampsia;PhD defense;pregnancy;MAB2; Fri, 15 Dec 2006 11:00:00 GMT Contribution of the abnormal expression of G protein coupled receptors in adrenal cortex tumorigenesis https://biosante-lab.fr/en/Pages/Theses/2005/Tania-Longo-Mazzuco.aspx Thesis presented April 05, 2005 by Tânia Longo Mazzuco. PhD thesis available as a pdf file. PhD defense;adrenocortical tumorigenesis;Cushing’s syndrome; Tue, 05 Apr 2005 10:00:00 GMT Biological effects and mechanical action of the receptor ALK-1 in angiogenesis https://biosante-lab.fr/en/Pages/Theses/2004/Samy-Lamouille.aspx Thesis presented January 22, 2004 by Samy Lamouille. PhD thesis available in Intranet as a pdf file. Rendu-Osler;ALK;BAL;Angiogenesis;PhD defense;endothelial cells; Thu, 22 Jan 2004 11:00:00 GMT Hormone-regulated angiogenesis in the adrenal cortex: ACTH regulation of the expression of angiogenic factors and of the zinc finger protein Tis11b https://biosante-lab.fr/en/Pages/Theses/2003/Delphine-Ciais.aspx Thesis presented December​ 19, 2003 by Delphine Ciais. PhD thesis available in Intranet as a pdf file. Tis11B;VEGF;Angiogenesis;PhD defense;zinc fingers;endothelial cells; Fri, 19 Dec 2003 11:00:00 GMT Effects of prolonged exposure to hypoxia on morphological changes of endothelial cells plated on fibrin gel https://biosante-lab.fr/en/Pages/Theses/2001/Fabienne-Baffert.aspx Thesis presented March 01, 2001 by Fabienne Baffert. PhD thesis available in Intranet as a pdf file. VEGF;PhD defense;hypoxia;endothelial cells; Thu, 01 Mar 2001 11:00:00 GMT Implication of protein kinase CK2 in the response to cellular stress. Study of the regulatory mechanisms involved in the regulation of CK2 https://biosante-lab.fr/en/Pages/Theses/2000/Delphine-Gerber-Scokaert.aspx Thesis presented October 20, 2000 by Delphine Gerber-Scokaert. PhD thesis available in Intranet as a pdf file. CK2;IMAC;PhD defense; Fri, 20 Oct 2000 10:00:00 GMT Involvement of protein kinase CK2 in cell proliferation https://biosante-lab.fr/en/Pages/Theses/2000/Franck-Lebrin.aspx Thesis presented October 17, 2000 by Franck Lebrin. CK2;PhD defense; Tue, 17 Oct 2000 10:00:00 GMT